What do you want to create?
It is all dependent on what you want to program with, if you are using Visual Studio then either Visual Basic or C# (.NET versions) are probably going to be for you. If you like you code a little more verbose then I would suggest Visual Basic, if not, then C#. These days with .NET support these languages are equally as powerful only have different syntax. Any Wrox book on your chosen language will help you get started. Good luck!