Gregory House is Hugh Laurie. The show "House" is Hugh Laurie. Don't think it is anything else. Most TV shows,The Good Wife series on dvd especially dramas, cannot succeed being built around just one performer or character, but here you have one of the few exceptions.

Take away Hugh Laurie and put in just about anyone else, and what do you have? A Medical Whodunnit buy Desperate Housewives season 1-6 with Archetypical characters played by chesty females and young good looking men, held together by an unlikable cur that tries to use sarcasm for wit. Hardly groundbreaking television.