1) yes. ms access can be used with ADO.NET, but if you have SQL Server, use it instead. Access does not do well on the web.
2) If you are using ADO.NET programatically, you can have the user select a file with the file dialog or something simmilar and use that for the source of your ADO.NET code. There is not much difference in that respect.
I haven't worked extensibly with ado.net, but it is much nicer than ADO.
Sal
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