hmmz very strange because if i reload the page the first of the userlist is selected and the websites are selected too.
When i select another user and then the first again no websites are selected.

I am not sure the page_load event is where you want to put this code. This is how I would do it (pseudo code)

'Page_Load
'If not page.ispostback then
'make a call to a method to setup the dropdownlist and listbox
'End if

'Method getData()
'retrive data from dataset and populate list box and ddl

'ddlSelectedIndexChanged(sender as object, e as eventargs) handles ddl.SelectedIndexChanged
'send dropdown value to a method that will retrive the values for the listbox

'getListBoxValues(ddlValue as string)
'Populat listbox

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tombert:
I think a bigger issue needs to be addressed and that is "Security":
     1) No One should have a list of userid's and their passwords unless u r a Security Manager and even then he/she should have the capabilities of unmasking the passwords;
     2) The Website administrator has the responsibility of adding a user or registering a userid to a web application and assigning a "common password" , which must be changed by the user at login time. The web site adminstrator may generate a list of userid's but even he should not know their passwords;
      3) It not clear in what you meant by allowing the userid's to edit websites from a list/listbox of websites. There are now in place Business Process Owners, Data Owners, Change Control Procedures that prevent anyone from making changes anywhere without proper documentation of said change(s).

My advice to you before going any futher is to check with the company's or corporation Security or CIO (Chief Information Officer) for what you are allowed to do and not do, expecially on a web site.

Don't mean to be the "Grim Reaper", but your questions could have serious Security impact.

Hope this helps.

first of all i want to thank you for your help/time. Second i will try your solution this afternoon.

Peace:
The security is no matter because it is a small project with only 1 admin and that will be me ;).

tombert:
It matters not the size of the project but the security of the userid's and their passwords is an issue. As website administrator, you may have the responsibility of registering the userid and assigning the first password, but allowing that user to change the password the first time they use it. You should not know their passwords. Even after they changed the passwords and forget, the only action you should take is "reseting" that password and not telling them what it was.... Also as website administrator, it is best that you track such changes as adding, changing and deleting a userid....

But let me know how it all works out for you and the small project on your next IT Audit....

Dont use a listbox, use a checkbox list.

bind your data to the checkbox list.

Check and uncheck the boxes and then on submit.

delete all relations in the one to one table you created

for x as integer = 0 to mycheckbox.items.count - 1
if mycheckbox.items(x).checked = true then
 insert this checked value back into that one to one table
end if
next

Dropdown lists are a pain to multi select especially when on the phone:) Checkboxes i have found alot easier.