If I'm understanding you correctly, you can set AutoPostBack=True in the dropdown control and then write a sub that "Handles" the OnChange event to point to files in the root directory. The links in the dropdown will be updated every time the dropdown populates from the database.
<asp:DropDownList ID="ddlAreaID" AutoPostBack="True" Runat="server" />
Private Sub ddlAreaID_SelectedIndexChanged(ByVal sender As Object, ByVal e As EventArgs) Handles ddlAreaID.SelectedIndexChanged
Do your pointing here although I don't understand exactly what you mean by "point". Do you mean open a file, read the contents of a directory, display a sample page from the book?
End Sub
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