I got this error when my code is:

MyMail.From = "sFrom";
            MyMail.To = txtto.Text.Trim();
            MyMail.Subject = "Test Mail";
            MyMail.Body = txtmessage.Text.Trim();




            SmtpMail.SmtpServer = mydomain;
            SmtpMail.Send(MyMail);

Anoop. H
Software Engineer,
CTIS, Trivandrum.

It would seem to me that the error message says it all.

What is the value of mydomain? Is that a valid mail server?

-Peter