Here is the source, the error is in teh Page_Load event. It indicates that Handles Me.Load is in error.
<%@ Page Language="
VB" %>
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
<script runat="server">
Protected Sub Page_Load(ByVal sender As Object, ByVal e As System.EventArgs)
Handles Me.Load
Label1.Text = "You entered " & TextBox1.Text
End Sub
Protected Sub Button1_Click(ByVal sender As Object, ByVal e As System.EventArgs)
TextBox1.Text = "You clicked button 1"
End Sub
Protected Sub Button2_Click(ByVal sender As Object, ByVal e As System.EventArgs)
TextBox1.Text = "You clicked button 2"
End Sub
</script>
<html xmlns="http://www.w3.org/1999/xhtml" >
<head runat="server">
<title>Untitled Page</title>
</head>
<body>
<form id="form1" runat="server">
<div>
<asp:Label ID="Label1" runat="server" Text="Label" Width="46px"></asp:Label><br />
<asp:TextBox ID="TextBox1" runat="server"></asp:TextBox><br />
<asp:Button ID="Button1" runat="server" Text="Button" OnClick="Button1_Click" />
<asp:Button ID="Button2" runat="server" Text="Button" OnClick="Button2_Click" /></div>
</form>
</body>
</html>