Simply put: if you send out 1000 emails to people that did not explicitly ASK you to send them said email that is spam and the possiblity of getting your domain banned exists.
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Read this if you want to know how to get a correct reply for your question:
http://www.catb.org/~esr/faqs/smart-questions.html
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.: Wrox Technical Editor :.
Wrox Books 24 x 7
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