No. You Global.asax will always raise its events (as far as i know) and there is no way to turn them off. Read this about the Application Begin Request: http://msdn2.microsoft.com/en-us/library/ms227673(vs.80).aspx
URL Rewriting is employed by plenty of sights, although you may not have noticed it. For example:
www.foo.com/product.aspx?id=3&cat=4 now with URL Rewriting a user may be able to type this
www.foo.com/Widgets/Super-Widget/ into their address bar and actually be directed to the page product.aspx with the id and category variables still in tact.
Its transparent to the user and it makes your sites much more
SEO friendly, but I digress. You achieve this by way of Regular Expressions and, it is possible, you could write an expression that would filter all requests to your website to one page.
This app is the most straight forward to get working:
http://urlrewriter.net/ and its free.
And you have this:
http://www.helicontech.com/download.htm (ISAPI Rewrite)
The latter of the 2 has 2 versions. The unpaid version can only be used within one domain, whereas the paid version can be configured to handle multiple domians. Also, because it is an ISAPI filter you have a bit of a preformance increase over URLRewriter but it is also a tad bit more complex to work with.
hth.
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Professional Search Engine Optimization with ASP.NET
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